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historical thesis statement - Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere. Zarghi A(1), Rao PN, Knaus EE. Author information: (1)Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada. As the results show, the inhibition of COXderived PGE2 synthesis (by %) remained significant 24 h after the administration of rofecoxib, which allowed once daily administration for the. Jun 03,  · Skip to Article Content; Skip to Article Information. evacuation homework help

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